# A new approach to microscopic modeling of a hole transfer in heteropolymer DNA

Source: [A new approach to microscopic modeling of a hole transfer in heteropolymer DNA](<https://www.sota2.com/research/paper/68fa2c111e209131ce84cd8e>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-24T15:07:30.341Z

Authors: A.S. Shigaev, O.A. Ponomarev, V.D. Lakhno

Published: 2013-03-25T11:40:35.000Z

## Abstract

Thermal oscillations of base pairs in the Peyrard-Bishop-Holstein model are simulated by stochastic fluctuations of base overlap integrals. Numerical investigation of the model is carried out for a hole transfer in $G\_1A\_2G\_3G\_4$ sequence which was previously studied experimentally by F. Lewis et al. A hole migration between $G\_1$ and $G\_3G\_4$ is determined by the matrix elements of the charge transition, but presence and amplitude of their stochastic fluctuations proved to play a key role in reproduction of the experimental kinetics. Good agreement with the experimental data was obtained for a wide range of the model parameters' combinations.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1303.6278>)

[PDF](<https://arxiv.org/pdf/1303.6278.pdf>)