# Microtubule Length-Regulation by Molecular Motors

Source: [Microtubule Length-Regulation by Molecular Motors](<https://www.sota2.com/research/paper/68fa2bac1e209131ce848fc9>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-24T14:20:50.879Z

Authors: Anna Melbinger, Louis Reese, Erwin Frey

Published: 2012-04-25T13:40:49.000Z

## Abstract

Length-regulation of microtubules (MTs) is essential for many cellular processes. Molecular motors like kinesin 8, which move along MTs and also act as depolymerases, are known as key players in MT dynamics. However, the regulatory mechanisms of length control remain elusive. Here, we investigate a stochastic model accounting for the interplay between polymerization kinetics and motor-induced depolymerization. We determine the dependence of MT length and variance on rate constants and motor concentration. Moreover, our analyses reveal how collective phenomena lead to a well-defined MT length.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1204.5655>)

[PDF](<https://arxiv.org/pdf/1204.5655.pdf>)