# Coupling of Active Motion and Advection Shapes Intracellular Cargo Transport

Source: [Coupling of Active Motion and Advection Shapes Intracellular Cargo Transport](<https://www.sota2.com/research/paper/68fa2b661e209131ce846bf1>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-24T14:11:40.875Z

Authors: P. Khuc Trong, J. Guck, R. E. Goldstein

Published: 2012-06-13T15:34:24.000Z

## Abstract

Intracellular cargo transport can arise from passive diffusion, active motor-driven transport along cytoskeletal filament networks, and passive advection by fluid flows entrained by such motor/cargo motion. Active and advective transport are thus intrinsically coupled as related, yet different representations of the same underlying network structure. A reaction-advection-diffusion system is used here to show that this coupling affects the transport and localization of a passive tracer in a confined geometry. For sufficiently low diffusion, cargo localization to a target zone is optimized either by low reaction kinetics and decoupling of bound and unbound states, or by a mostly disordered cytoskeletal network with only weak directional bias. These generic results may help to rationalize subtle features of cytoskeletal networks, for example as observed for microtubules in fly oocytes.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/1206.2842>)

[PDF](<https://arxiv.org/pdf/1206.2842.pdf>)