# Resonant effects in a voltage-activated channel gating

Source: [Resonant effects in a voltage-activated channel gating](<https://www.sota2.com/research/paper/68fa27812c2a3760193c2f32>)

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Data updated: 2025-10-24T11:59:55.756Z

Authors: Ewa Gudowska-Nowak, Bartlomiej Dybiec, Henrik Flyvbjerg

Published: 2006-10-30T10:27:31.000Z

## Abstract

The non-selective voltage activated cation channel from the human red cells, which is activated at depolarizing potentials, has been shown to exhibit counter-clockwise gating hysteresis. We have analyzed the phenomenon with the simplest possible phenomenological models by assuming $2\\times 2$ discrete states, i.e. two normal open/closed states with two different states of \`\`gate tension.'' Rates of transitions between the two branches of the hysteresis curve have been modeled with single-barrier kinetics by introducing a real-valued \`\`reaction coordinate'' parameterizing the protein's conformational change. When described in terms of the effective potential with cyclic variations of the control parameter (an activating voltage), this model exhibits typical \`\`resonant effects'': synchronization, resonant activation and stochastic resonance. Occurrence of the phenomena is investigated by running the stochastic dynamics of the model and analyzing statistical properties of gating trajectories.

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/cond-mat/0610826>)

[PDF](<https://arxiv.org/pdf/cond-mat/0610826.pdf>)