# Origins of Chevron Rollovers in Non-Two-State Protein Folding Kinetics

Source: [Origins of Chevron Rollovers in Non-Two-State Protein Folding Kinetics](<https://www.sota2.com/research/paper/68fa26062c2a3760193b5ee9>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-24T11:06:39.502Z

Authors: Huseyin Kaya, Hue Sun Chan

Published: 2003-02-14T17:33:33.000Z

## Abstract

Chevron rollovers of some proteins imply that their logarithmic folding rates are nonlinear in native stability. This is predicted by lattice and continuum G\\=o models to arise from diminished accessibilities of the ground state from transiently populated compact conformations under strongly native conditions. Despite these models' native-centric interactions, the slowdown is due partly to kinetic trapping caused by some of the folding intermediates' nonnative topologies. Notably, simple two-state folding kinetics of small single-domain proteins are not reproduced by common G\\=o-like schemes.

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/cond-mat/0302305>)

[PDF](<https://arxiv.org/pdf/cond-mat/0302305.pdf>)