# Cooperativity and Stability in a Langevin Model of Protein Folding

Source: [Cooperativity and Stability in a Langevin Model of Protein Folding](<https://www.sota2.com/research/paper/68fa244a2c2a3760193a2224>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-27T02:57:37.755Z

Authors: Gabriel F. Berriz, Alexander M. Gutin, Eugene I. Shakhnovich

Published: 1996-10-14T12:59:47.000Z

## Abstract

We present two simplified models of protein dynamics based on Langevin's equation of motion in a viscous medium. We explore the effect of the potential energy function's symmetry on the kinetics and thermodynamics of simulated folding. We find that an isotropic potential energy function produces, at best, a modest degree of cooperativity. In contrast, a suitable anisotropic potential energy function delivers strong cooperativity.

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/cond-mat/9610105>)

[PDF](<https://arxiv.org/pdf/cond-mat/9610105.pdf>)