# Stop-and-go kinetics in amyloid fibrillation

Source: [Stop-and-go kinetics in amyloid fibrillation](<https://www.sota2.com/research/paper/68fa24042c2a37601939e08c>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-28T13:52:41.591Z

Authors: Jesper Fonslet, Christian Beyschau Andersen, Sandeep Krishna, Simone Pigolotti, Hisashi Yagi, Yuji Goto, Daniel Otzen, Mogens H. Jensen, Jesper Ferkinghoff-Borg

Published: 2009-10-21T08:49:12.000Z

## Abstract

Many human diseases are associated with protein aggregation and fibrillation. We present experiments on in vitro glucagon fibrillation using total internal reflection fluorescence microscopy, providing real-time measurements of single-fibril growth. We find that amyloid fibrils grow in an intermittent fashion, with periods of growth followed by long pauses. The observed exponential distributions of stop and growth times support a Markovian model, in which fibrils shift between the two states with specific rates. Remarkably, the probability of being in the growing (stopping) state is very close to 1/4 (3/4) in all experiments, even if the rates vary considerably. This finding suggests the presence of 4 independent conformations of the fibril tip; we discuss this possibility in terms of the existing structural knowledge.

## Recorded benchmark results

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/0910.4020>)

[PDF](<https://arxiv.org/pdf/0910.4020.pdf>)