# Predicting the Drug Release Kinetics of Matrix Tablets

Source: [Predicting the Drug Release Kinetics of Matrix Tablets](<https://www.sota2.com/research/paper/68fa23f52c2a37601939d774>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-28T13:52:41.004Z

Authors: Boris Baeumer, Lipika Chatterjee, Peter Hinow, Thomas Rades, Ami Radunskaya, Ian Tucker

Published: 2008-10-29T17:36:40.000Z

## Abstract

In this paper we develop two mathematical models to predict the release kinetics of a water soluble drug from a polymer/excipient matrix tablet. The first of our models consists of a random walk on a weighted graph, where the vertices of the graph represent particles of drug, excipient and polymer, respectively. The graph itself is the contact graph of a multidisperse random sphere packing. The second model describes the dissolution and the subsequent diffusion of the active drug out of a porous matrix using a system of partial differential equations. The predictions of both models show good qualitative agreement with experimental release curves. The models will provide tools for designing better controlled release devices.

## Recorded benchmark results

A research result applies to its stated dataset, split, metric and evaluation configuration. Compare like-for-like settings, preserve the metric's unit and direction, and distinguish paper-reported results from independent reproduction. The best result recorded here is not a claim of exhaustive, current global coverage.

## Original sources and implementation

[Original paper](<https://arxiv.org/abs/0810.5323>)

[PDF](<https://arxiv.org/pdf/0810.5323.pdf>)