# Impact of Short- and Long-range Forces on Protein Conformation and Adsorption Kinetics

Source: [Impact of Short- and Long-range Forces on Protein Conformation and Adsorption Kinetics](<https://www.sota2.com/research/paper/68fa20df7a2b558e29333dac>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-23T23:20:07.686Z

Authors: Anthony Quinn, Hubert Mantz, Karin Jacobs, Markus Bellion, Ludger Santen

Published: 2006-07-14T18:30:14.000Z

## Abstract

We have studied the adsorption kinetics of the protein amylase at solid/liquid interfaces. Offering substrates with tailored properties, we are able to separate the impact of short- and long-range interactions. By means of a colloidal Monte Carlo approach including conformational changes of the adsorbed proteins induced by density fluctuations, we develop a scenario that is consistent with the experimentally observed three-step kinetics on specific substrates. Our observations show that not only the surface chemistry determines the properties of an adsorbed protein layer but also the van der Waals contributions of a composite substrate may lead to non-negligible effects.

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/cond-mat/0607384>)

[PDF](<https://arxiv.org/pdf/cond-mat/0607384.pdf>)