# Topological complexity, contact order and protein folding rates

Source: [Topological complexity, contact order and protein folding rates](<https://www.sota2.com/research/paper/68fa1e377a2b558e29320d33>)

Collection index: [llms.txt](<https://www.sota2.com/research/llms.txt>)

Data updated: 2025-10-23T17:06:32.971Z

Authors: P.F.N. Faisca, R.C. Ball

Published: 2002-05-29T18:03:23.000Z

## Abstract

Monte Carlo simulations of protein folding show the emergence of a strong correlation between the relative contact order parameter, CO, and the folding time, t, of two-state folding proteins for longer chains with number of amino acids, N\>=54, and higher contact order, CO \> 0.17. The correlation is particularly strong for N=80 corresponding to slow and more complex folding kinetics. These results are qualitatively compatible with experimental data where a general trend towards increasing t with CO is indeed observed in a set of proteins with chain length ranging from 41 to 154 amino acids.

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## Original sources and implementation

[Original paper](<https://arxiv.org/abs/cond-mat/0205631>)

[PDF](<https://arxiv.org/pdf/cond-mat/0205631.pdf>)